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Table 1 Radiotracers radiolabeled using [11C]carbon monoxide, the corresponding biological target, and disease relevance

From: [11C]Carbon monoxide: advances in production and application to PET radiotracer development over the past 15 years

Entry

Radiotracer

Biological target

Disease relevance

Reference(s)

1

Y Y5 receptor

Weight loss

(Kealey et al. 2011)

2

D2 receptor

Movement disorders, schizophrenia

(Dahl et al. 2015b), (Rahman et al. 2015), (Andersen et al. 2015)

3

D2 receptor

Movement disorders, schizophrenia

(Dahl et al. 2015b)

4

TSPO

Neuroinflammation

(Rahman and Långström 2007)

5

CB1

Neuropsychiatric disorders (e.g., schizophrenia, anxiety, and depression)

(Donohue et al. 2008)

6

mGluR1

Anxiety, mood disorders, stroke, epilepsy, pain, and schizophrenia

(Hong et al. 2015)

7

HDAC6

Neurodegenerative disorders and cancer

(Lu et al. 2016)

8

BACE-1

Alzheimer’s disease

(Nordeman et al. 2014)

9

5-HT1B

Migraine, depression, and anxiety

(Lindberg et al. 2019)

10

OGA

Alzheimer’s disease

a

11

H3R

Neuropsychiatric and neurodegenerative disorders

(Dahl et al. 2013), (Dahl et al. 2018)

12

H3R

Neuropsychiatric and neurodegenerative disorders

(Siméon et al. 2017)

13

Serine/threonine kinase

Melanomas

(Slobbe et al. 2017)

14

sHE

Inflammation and neuropathic pain

(Roslin et al. 2017)

15

TG2

Celiac disease, cancer, fibrosis, and neurodegenerative diseases (e.g., Alzheimer’s, Huntington’s, Parkinson’s diseases)

(van der Wildt et al. 2016)

16

GAD

Neuropsychiatric disease (e.g., schizophrenia)

(Taddei et al. 2017b)b

17

cPLA2α

Oxidative stress and neuroinflammation

(Fisher et al. 2018)

18

Functionalized [11C]synthon for potential PET radiotracers (e.g., barbiturates)

(Barletta et al. 2006)

19

AT2R

Prostate cancer and idiopathic pulmonary fibrosis

(Stevens et al. 2016)

20

Efflux transporter P-gp

Neurological disease (e.g., Alzheimer’s disease)

(Verbeek et al. 2012)

21

TKI

Cancer

(Poot et al. 2013)

22

5-HT1B/1D

Locomotion and anxiety

(Lindhe et al. 2011)

  1. aLu S, Haskali MB, Ruley KM, Dreyfus NJ-F, DuBois SL, Soumen P, et al. Discovery and development of 18F- and 11C-labeled LSN3316612 as positron emission tomography radioligands for quantifying O-linked-β-N-acetyl-glucosamine hydrolase in brain, submitted. bTaddei C, Filp U, Pekošak A, Poot AJ, Windhorst AD, Gee AD. Synthesis of a 11C-tracer for potential brain glutamic acid decarboxylase (GAD) targeting, submitted