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Table 1 Radiotracers radiolabeled using [11C]carbon monoxide, the corresponding biological target, and disease relevance

From: [11C]Carbon monoxide: advances in production and application to PET radiotracer development over the past 15 years

Entry Radiotracer Biological target Disease relevance Reference(s)
1 Y Y5 receptor Weight loss (Kealey et al. 2011)
2 D2 receptor Movement disorders, schizophrenia (Dahl et al. 2015b), (Rahman et al. 2015), (Andersen et al. 2015)
3 D2 receptor Movement disorders, schizophrenia (Dahl et al. 2015b)
4 TSPO Neuroinflammation (Rahman and Långström 2007)
5 CB1 Neuropsychiatric disorders (e.g., schizophrenia, anxiety, and depression) (Donohue et al. 2008)
6 mGluR1 Anxiety, mood disorders, stroke, epilepsy, pain, and schizophrenia (Hong et al. 2015)
7 HDAC6 Neurodegenerative disorders and cancer (Lu et al. 2016)
8 BACE-1 Alzheimer’s disease (Nordeman et al. 2014)
9 5-HT1B Migraine, depression, and anxiety (Lindberg et al. 2019)
10 OGA Alzheimer’s disease a
11 H3R Neuropsychiatric and neurodegenerative disorders (Dahl et al. 2013), (Dahl et al. 2018)
12 H3R Neuropsychiatric and neurodegenerative disorders (Siméon et al. 2017)
13 Serine/threonine kinase Melanomas (Slobbe et al. 2017)
14 sHE Inflammation and neuropathic pain (Roslin et al. 2017)
15 TG2 Celiac disease, cancer, fibrosis, and neurodegenerative diseases (e.g., Alzheimer’s, Huntington’s, Parkinson’s diseases) (van der Wildt et al. 2016)
16 GAD Neuropsychiatric disease (e.g., schizophrenia) (Taddei et al. 2017b)b
17 cPLA2α Oxidative stress and neuroinflammation (Fisher et al. 2018)
18 Functionalized [11C]synthon for potential PET radiotracers (e.g., barbiturates) (Barletta et al. 2006)
19 AT2R Prostate cancer and idiopathic pulmonary fibrosis (Stevens et al. 2016)
20 Efflux transporter P-gp Neurological disease (e.g., Alzheimer’s disease) (Verbeek et al. 2012)
21 TKI Cancer (Poot et al. 2013)
22 5-HT1B/1D Locomotion and anxiety (Lindhe et al. 2011)
  1. aLu S, Haskali MB, Ruley KM, Dreyfus NJ-F, DuBois SL, Soumen P, et al. Discovery and development of 18F- and 11C-labeled LSN3316612 as positron emission tomography radioligands for quantifying O-linked-β-N-acetyl-glucosamine hydrolase in brain, submitted. bTaddei C, Filp U, Pekošak A, Poot AJ, Windhorst AD, Gee AD. Synthesis of a 11C-tracer for potential brain glutamic acid decarboxylase (GAD) targeting, submitted