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Table 5 Summary of in vivo biodistribution studies of [225Ac]Ac-CCZ01048 at 2 h post-injection. Statistical analysis between non-blocked and blocked experiments was performed using the Student’s t-test (* p < 0.05; ** p < 0.005; n = 4 for each animal experiment)

From: Evaluation of polydentate picolinic acid chelating ligands and an α-melanocyte-stimulating hormone derivative for targeted alpha therapy using ISOL-produced 225Ac

Study

Molar activity (kBq/nmol)

Tumour (%ID/g)

Kidney (%ID/g)

Blood (%ID/g)

Tumour: blood

Tumour: bone

Tumour: kidney

Non-blocked

>  200

5.23 ± 1.78

4.83 ± 1.58

0.25 ± 0.07

20.42 ± 3.38

23.16 ± 10.32

1.09 ± 0.11

Blocked

1.6

1.15 ± 0.21**

8.85 ± 1.19*

0.34 ± 0.09

3.50 ± 0.72**

1.22 ± 0.27**

0.13 ± 0.04**