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Table 1 Summary of 225Ra and 225Ac production runs at ISAC, TRIUMF’s ISOL facility. aEE = extraction electrode; bLIS = laser ionization source

From: Evaluation of polydentate picolinic acid chelating ligands and an α-melanocyte-stimulating hormone derivative for targeted alpha therapy using ISOL-produced 225Ac

Implantation parameters

Ion beam intensity [ions/s]

Activity Produced [MBq]

Date

duration [h]

EEa

LISb

225Ra

225Ac

225Ra

225Ac

Dec ‘15

13.3

Off

Off

3.2 × 107

3.8 × 106

0.19

0.16

Apr ‘16

44.8

Off

On

4.0 × 106

1.0 × 107

0.99

1.40

May ‘16

48.9

1.13

1.35

Aug ‘16

21.6

On

On

1.6 × 108

5.7 × 107

7.1

10.5

Dec ‘16

45.0

On

On

9.3 × 107

1.3 × 108

6.8

18.0

Apr ‘17

80.7

Off

On

9.0 × 107

2.8 × 106

7.5

1.7

Sept ‘18

~ 40

On

Off

1.0 × 108

1.6 × 107

8.6

9.4