Current radiotracers to image neurodegenerative diseases

EJNMMI Radiopharmacy and Chemistry

Table 3 Summary of typical hypometabolism patterns in [¹⁸F] FDG PET in different neurodegenerative diseases

Disease	Relative glucose metabolism reduction	Disease	Relative glucose metabolism reduction
AD	PCC, parieto-temporal. Advanced: frontal	PD/DLB	Parieto-temporo-occiptal^a
PCA	Parieto-occipital	PSP	Mesial and dorsolateral, caudate, thalamus, upper brain stem^a
lvPPA	Parieto-temporal (left pronounced)	CBS	Fronto-parietal, striatal (asymmetric)^a
bvFTD	Frontal, ACC, right anterior insula. Advanced: temporal and subcortical	MSA	Striatum (posterior putamen), cerebellum^a
svPPA	Anterior temporal, subcallosal, amygdalae, frontal midline	HD	Striatum, insula, posterior cingulate, prefrontal, occipital cortex^b
nfvPPA	Left hemisphere, frontotemporal, insula. Advanced: parieto-temporal

ACC Anterior cingulate cortex, AD Alzheimer’s disease, bvFTD Behavioural variant frontotemporal dementia, CBS Corticobasal syndrome, DLB Dementia with Lewy-bodies, FDG Fluorodesoxyglucose, HD Huntington’s disease, lvPPA Logopenic variant primary progressive aphasia, MSA Multisystem atrophy, nfvPPA non-fluent/agrammatic variant primary progressive aphasia, PCA Posterior cortical atrophy, PCC Posterior cingulate cortex, PD Parkinson’s disease, PET Positron emission tomography, PSP Progressive supranuclear palsy, svPPA Semantic variant primary progressive aphasia
^a(Meyer et al. 2017) ^b(Tang et al. 2013)