From: Current radiotracers to image neurodegenerative diseases
Disease | Aβ plaques | Tau deposits | α- synuclein | TDP-43 | Other pathologies |
---|---|---|---|---|---|
AD | ++ (in up to 90%)l | ++ 3R/4R | – | – | – |
PCA | ++ (in up to 78%)a,c | ++ 3R/4R (AD in ≈ 76%), 4R (CBD in ≈ 9,5%)c | + Lewy-bodies (in ≈ 14%)c | – | (+) Prion-associated diseases |
lvPPA | ++ (in up to 56%)b | ++ 3R/4R (AD in up to 56%)b, other subtypes (in ≈ 10%)b | (+) Lewy-bodies (< 10%)e | + (in up to 25%, mainly type A)d, | (+) CJD |
bvFTD | + (in up to 13%)f | + 4R (CBD in up to ≈ 9%)h 4R (PSP ≈ 8%)h 3R (PiD in ≈ 7%)h 3R/4R (AD in ≈ 13%)h | – | ++ (type A in ≈8%, type B in ≈23%, type C in ≈7% type U in ≈ 10%)h | (+) FTLD-FUS in ≈7%h |
svPPA | + (in up to 14%)b | + 3R (PiD in up to 15%)b | – | ++ (in up to 86%, pre-dominantly type C)b | – |
nfvPPA | + (in up to 12%)g | ++ 4R (CBD in up to ≈ 54%)h 4R (PSP ≈ 18%)g,h 3R (PiD in ≈ 12%)g 3R/4R (AD in ≈ 12%)g | (+) Lewy-bodies (< 10%)b,g | + (type A in up to 18%) g,h | – |
PD/DLB | ++ (PD in up to 15%, DLB in up to 80%)k | (+) 4R (PSP in ≈ 8%)i 4R (CBD in ≈ 2%)i | ++ Lewy bodies (in up to 77%)i,j α- synuclein (MSA in ≈5%)i | – | – |
HD | – | + 3R/4R | – | ++ Huntingtin | – |