From: The various therapeutic applications of the medical isotope holmium-166: a narrative review
Study title | Device/ drug | Tumour type | Compound | Sponsor | Time path | ClinicalTrials.gov Identifier | Reference(s) |
---|---|---|---|---|---|---|---|
QuiremSpheres Observational Study | device | Liver cancer, non-resectable tumors | Holmium-166 polylactic microspheres | Terumo Europe N.V. | 2018 - (recruiting) | NCT03563274 | Â |
Holmium Radioembolization as Adjuvant Treatment to RFA for Early Stage HCC: Dose Finding Study | device | hepatocellular carcinoma | RFA + Holmium-166 polylactic microspheres | Leiden University Medical Center The Netherlands | 2018 - (recruiting) | NCT03437382 |  |
HEPAR Primary: Holmium-166-radioembolization in Hepatocellular Carcinoma Patients | device | hepatocellular carcinoma | SIRT Holmium-166 PLLA microspheres | Erasmus Medical Center Rotterdam, University Medical Center Utrecht The Netherlands | 2017 - (recruiting) | NCT03379844 | Â |
Feasibility of Holmium-166 Micro Brachytherapy in Head and Neck Tumors | device | head-and-neck neoplasms | SIRT Holmium-166 PLLA microspheres | University Medical Center Utrecht The Netherlands | 2016–2018 (terminated, slow accrual) | NCT02975739 |  |
Holmium-166-radioembolization in NET After Lutetium-177-dotatate; an Efficacy Study | device | neuroendocrine tumours in the liver | SIRT Holmium-166 PLLA microspheres | University Medical Center Utrecht, The Netherlands | 2016 - (recruiting) | NCT02067988 | |
Surefire Infusion System vs. Standard Microcatheter Use During Holmium-166 Radioembolization | device | colorectal metastases in the liver | SIRT Holmium-166-PLLA microspheres | University Medical Center Utrecht The Netherlands | 2016 - (recruiting) | NCT02208804 | |
Radioactive Holmium Microspheres for the Treatment of Unresectable Liver Metastases | device | liver neoplasms | SIRT Holmium-166-PLLA microspheres | University Medical Center Utrecht The Netherlands | 2012–2015 (completed) | NCT01612325 | (Prince et al. 2018; Braat et al. 2018a; Prince et al. 2015; van Nierop et al. 2018) |
Radioactive Holmium Microspheres for the Treatment of Liver Metastases | device | liver metastases liver tumours | SIRT Holmium-166-PLLA microspheres | University Medical Center Utrecht Utrecht, Netherlands | 2009–2012 (completed) | NCT01031784 | (Smits et al. 2012; van de Maat et al. 2013; Smits et al. 2013; Smits et al. 2010; Prince et al. 2014; Elschot et al. 2014; Braat et al. 2018a; van Nierop et al. 2018) |
Radiation Therapy Using Holmium Ho 166 DOTMP Plus Melphalan and Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma | drug | multiple myeloma and plasma cell neoplasm | melphalan + Holmium-166- DOTMP | Fred Hutchinson Cancer Research CenterSeattle, Washington, United States | 2004–2010 (completed) | NCT00004158 |  |
Melphalan With or Without Holmium Ho 166 DOTMP Followed by Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma | drug | multiple myeloma and plasma cell neoplasm | melphalan + Holmium-166- DOTMP | Fred Hutchinson Cancer Research Center Seattle, Washington, United States | 2004–2010 (completed) | NCT00008229 |  |
Study Comparing STR (Skeletal Targeted Radiotherapy) Plus Melphalan to Melphalan Alone, With Stem Cell Transplant in Multiple Myeloma | drug | multiple myeloma | Holmium-166- DOTMP | Poniard Pharmaceuticals | 2004–2009 (terminated) | NCT00083564 | |
Holmium Ho 166 DOTMP Followed by Peripheral Stem Cell Transplantation in Treating Patients With Metastatic Ewing's Sarcoma or Rhabdomyosarcoma That Has Spread to the Bone | drug | metastatic cancer, sarcoma | Holmium-166- DOTMP | Fred Hutchinson Cancer Research Center Seattle, Washington, United State | 2003–2011 (completed) | NCT00006234 |  |
Chemotherapy, Holmium Ho 166 DOTMP, and Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma | drug | multiple myeloma and plasma cell neoplasm | Holmium-166- DOTMP | Poniard Pharmaceuticals | 2003–2009 (completed) | NCT00045136 |  |
A Trial of Skeletal Targeted Radiotherapy Using Holmium-166-DOTMP in Patients With Multiple Myeloma | drug | multiple myeloma | Holmium-166-DOTMP | Poniard Pharmaceuticals | 2002–2009 (terminated, business reasons) | NCT00039754 |  |