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Table 2 Clinical studies published at www.clinicaltrials.gov in which a compound with holmium-166 is used

From: The various therapeutic applications of the medical isotope holmium-166: a narrative review

Study title

Device/ drug

Tumour type

Compound

Sponsor

Time path

ClinicalTrials.gov Identifier

Reference(s)

QuiremSpheres Observational Study

device

Liver cancer, non-resectable tumors

Holmium-166 polylactic microspheres

Terumo Europe N.V.

2018 - (recruiting)

NCT03563274

 

Holmium Radioembolization as Adjuvant Treatment to RFA for Early Stage HCC: Dose Finding Study

device

hepatocellular carcinoma

RFA + Holmium-166 polylactic microspheres

Leiden University Medical Center The Netherlands

2018 - (recruiting)

NCT03437382

 

HEPAR Primary: Holmium-166-radioembolization in Hepatocellular Carcinoma Patients

device

hepatocellular carcinoma

SIRT

Holmium-166 PLLA microspheres

Erasmus Medical Center Rotterdam, University Medical Center Utrecht The Netherlands

2017 - (recruiting)

NCT03379844

 

Feasibility of Holmium-166 Micro Brachytherapy in Head and Neck Tumors

device

head-and-neck neoplasms

SIRT

Holmium-166 PLLA microspheres

University Medical Center Utrecht The Netherlands

2016–2018

(terminated, slow accrual)

NCT02975739

 

Holmium-166-radioembolization in NET After Lutetium-177-dotatate; an Efficacy Study

device

neuroendocrine tumours in the liver

SIRT

Holmium-166 PLLA microspheres

University Medical Center Utrecht, The Netherlands

2016 - (recruiting)

NCT02067988

(Braat et al. 2018b; van Nierop et al. 2018)

Surefire Infusion System vs. Standard Microcatheter Use During Holmium-166 Radioembolization

device

colorectal metastases in the liver

SIRT

Holmium-166-PLLA microspheres

University Medical Center Utrecht The Netherlands

2016 - (recruiting)

NCT02208804

(van Nierop et al. 2018; van den Hoven et al. 2016)

Radioactive Holmium Microspheres for the Treatment of Unresectable Liver Metastases

device

liver neoplasms

SIRT

Holmium-166-PLLA microspheres

University Medical Center Utrecht The Netherlands

2012–2015

(completed)

NCT01612325

(Prince et al. 2018; Braat et al. 2018a; Prince et al. 2015; van Nierop et al. 2018)

Radioactive Holmium Microspheres for the Treatment of Liver Metastases

device

liver metastases

liver tumours

SIRT

Holmium-166-PLLA microspheres

University Medical Center Utrecht Utrecht, Netherlands

2009–2012

(completed)

NCT01031784

(Smits et al. 2012; van de Maat et al. 2013; Smits et al. 2013; Smits et al. 2010; Prince et al. 2014; Elschot et al. 2014; Braat et al. 2018a; van Nierop et al. 2018)

Radiation Therapy Using Holmium Ho 166 DOTMP Plus Melphalan and Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma

drug

multiple myeloma and plasma cell neoplasm

melphalan +

Holmium-166- DOTMP

Fred Hutchinson Cancer Research CenterSeattle, Washington, United States

2004–2010

(completed)

NCT00004158

 

Melphalan With or Without Holmium Ho 166 DOTMP Followed by Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma

drug

multiple myeloma and plasma cell neoplasm

melphalan +

Holmium-166- DOTMP

Fred Hutchinson Cancer Research Center Seattle, Washington, United States

2004–2010

(completed)

NCT00008229

 

Study Comparing STR (Skeletal Targeted Radiotherapy) Plus Melphalan to Melphalan Alone, With Stem Cell Transplant in Multiple Myeloma

drug

multiple myeloma

Holmium-166- DOTMP

Poniard Pharmaceuticals

2004–2009

(terminated)

NCT00083564

(Giralt et al. 2003; Breitz et al. 2003b)

Holmium Ho 166 DOTMP Followed by Peripheral Stem Cell Transplantation in Treating Patients With Metastatic Ewing's Sarcoma or Rhabdomyosarcoma That Has Spread to the Bone

drug

metastatic cancer, sarcoma

Holmium-166- DOTMP

Fred Hutchinson Cancer Research Center Seattle, Washington, United State

2003–2011

(completed)

NCT00006234

 

Chemotherapy, Holmium Ho 166 DOTMP, and Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma

drug

multiple myeloma and plasma cell neoplasm

Holmium-166- DOTMP

Poniard Pharmaceuticals

2003–2009

(completed)

NCT00045136

 

A Trial of Skeletal Targeted Radiotherapy Using Holmium-166-DOTMP in Patients With Multiple Myeloma

drug

multiple myeloma

Holmium-166-DOTMP

Poniard Pharmaceuticals

2002–2009

(terminated, business reasons)

NCT00039754

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