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Table 2 Clinical studies published at www.clinicaltrials.gov in which a compound with holmium-166 is used

From: The various therapeutic applications of the medical isotope holmium-166: a narrative review

Study title Device/ drug Tumour type Compound Sponsor Time path ClinicalTrials.gov Identifier Reference(s)
QuiremSpheres Observational Study device Liver cancer, non-resectable tumors Holmium-166 polylactic microspheres Terumo Europe N.V. 2018 - (recruiting) NCT03563274  
Holmium Radioembolization as Adjuvant Treatment to RFA for Early Stage HCC: Dose Finding Study device hepatocellular carcinoma RFA + Holmium-166 polylactic microspheres Leiden University Medical Center The Netherlands 2018 - (recruiting) NCT03437382  
HEPAR Primary: Holmium-166-radioembolization in Hepatocellular Carcinoma Patients device hepatocellular carcinoma SIRT Holmium-166 PLLA microspheres Erasmus Medical Center Rotterdam, University Medical Center Utrecht The Netherlands 2017 - (recruiting) NCT03379844  
Feasibility of Holmium-166 Micro Brachytherapy in Head and Neck Tumors device head-and-neck neoplasms SIRT Holmium-166 PLLA microspheres University Medical Center Utrecht The Netherlands 2016–2018 (terminated, slow accrual) NCT02975739  
Holmium-166-radioembolization in NET After Lutetium-177-dotatate; an Efficacy Study device neuroendocrine tumours in the liver SIRT Holmium-166 PLLA microspheres University Medical Center Utrecht, The Netherlands 2016 - (recruiting) NCT02067988 (Braat et al. 2018b; van Nierop et al. 2018)
Surefire Infusion System vs. Standard Microcatheter Use During Holmium-166 Radioembolization device colorectal metastases in the liver SIRT Holmium-166-PLLA microspheres University Medical Center Utrecht The Netherlands 2016 - (recruiting) NCT02208804 (van Nierop et al. 2018; van den Hoven et al. 2016)
Radioactive Holmium Microspheres for the Treatment of Unresectable Liver Metastases device liver neoplasms SIRT Holmium-166-PLLA microspheres University Medical Center Utrecht The Netherlands 2012–2015 (completed) NCT01612325 (Prince et al. 2018; Braat et al. 2018a; Prince et al. 2015; van Nierop et al. 2018)
Radioactive Holmium Microspheres for the Treatment of Liver Metastases device liver metastases liver tumours SIRT Holmium-166-PLLA microspheres University Medical Center Utrecht Utrecht, Netherlands 2009–2012 (completed) NCT01031784 (Smits et al. 2012; van de Maat et al. 2013; Smits et al. 2013; Smits et al. 2010; Prince et al. 2014; Elschot et al. 2014; Braat et al. 2018a; van Nierop et al. 2018)
Radiation Therapy Using Holmium Ho 166 DOTMP Plus Melphalan and Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma drug multiple myeloma and plasma cell neoplasm melphalan + Holmium-166- DOTMP Fred Hutchinson Cancer Research CenterSeattle, Washington, United States 2004–2010 (completed) NCT00004158  
Melphalan With or Without Holmium Ho 166 DOTMP Followed by Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma drug multiple myeloma and plasma cell neoplasm melphalan + Holmium-166- DOTMP Fred Hutchinson Cancer Research Center Seattle, Washington, United States 2004–2010 (completed) NCT00008229  
Study Comparing STR (Skeletal Targeted Radiotherapy) Plus Melphalan to Melphalan Alone, With Stem Cell Transplant in Multiple Myeloma drug multiple myeloma Holmium-166- DOTMP Poniard Pharmaceuticals 2004–2009 (terminated) NCT00083564 (Giralt et al. 2003; Breitz et al. 2003b)
Holmium Ho 166 DOTMP Followed by Peripheral Stem Cell Transplantation in Treating Patients With Metastatic Ewing's Sarcoma or Rhabdomyosarcoma That Has Spread to the Bone drug metastatic cancer, sarcoma Holmium-166- DOTMP Fred Hutchinson Cancer Research Center Seattle, Washington, United State 2003–2011 (completed) NCT00006234  
Chemotherapy, Holmium Ho 166 DOTMP, and Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma drug multiple myeloma and plasma cell neoplasm Holmium-166- DOTMP Poniard Pharmaceuticals 2003–2009 (completed) NCT00045136  
A Trial of Skeletal Targeted Radiotherapy Using Holmium-166-DOTMP in Patients With Multiple Myeloma drug multiple myeloma Holmium-166-DOTMP Poniard Pharmaceuticals 2002–2009 (terminated, business reasons) NCT00039754