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Table 1 Representative examples of carriers that have been loaded or conjugated to holmium and to the dysprosium/holmium generator

From: The various therapeutic applications of the medical isotope holmium-166: a narrative review

Bone seeking agents DOTMP (Bayouth et al. 1995a; Bayouth et al. 1995b; Parks et al. 1993; Giralt et al. 2003; Breitz et al. 2006; Rajendran et al. 2002; Ueno et al. 2009; Breitz et al. 2003a)
EDTMP (Sohaib et al. 2011; Bahrami-Samani et al. 2010; Appelbaum et al. 1992; Louw et al. 1996)
PAM (Vaez-Tehrani et al. 2016)
TTHMP (Yousefnia et al. 2014)
APDDMP (Marques et al. 2006; Zeevaart et al. 2001)
Antibodies DO3A-4B4 (Ballard et al. 2011)
CHX-A"DTPA-6D2 (Thompson et al. 2014)
DOTA-CC49 MeO-DOTA-CC49 (Mohsin et al. 2006; Mohsin et al. 2011)
Other complexes DTPA (Majali et al. 2001; Hong et al. 2002)
DOTA (Das et al. 2003)
Chitosan (Ha et al. 2013; Huh et al. 2005; Kim et al. 2006; Kwak et al. 2005; Suzuki et al. 1998; Lee et al. 2006; Cho et al. 2010; Song et al. 2001; Lee et al. 2003)
Oxine lipiodol (Das et al. 2009b)
PMMA (Hirsch et al. 2008)
Microparticles Glass (Costa et al. 2009; Brown et al. 1991)
Resin (Turner et al. 1994; Subramanian et al. 2018; Costa and Osso Junior 2008)
Alginate (Zielhuis et al. 2007)
Lipiodol-alginate (Oerlemans et al. 2015)
AcAc-PLLA (Nijsen et al. 1999; Mumper et al. 1992)
Polyester (Mumper and Jay 1992)
AcAc (Bult et al. 2012; Bult et al. 2009)
PO4 (Bult et al. 2012; Arranja et al. 2018)
Hydroxiapatite (Das et al. 2009a; Unni et al. 2002)
Ferric hydroxide (FHMA) (Makela et al. 2004; Makela et al. 2003b; Vuorela et al. 2005; Kraft et al. 2007; Cho et al. 2010; Makela et al. 2004; Ofluoglu et al. 2002)
Nanoparticles Mesoroporous silica nanoparticles (Di Pasqua et al. 2013)
Mesoroporous carbon nanoparticles (Kim et al. 2017)
AcAc-DSPE-PEG (Di Pasqua et al. 2012)
AcAc-PLLA (Hamoudeh et al. 2008)
AcAc (Bult et al. 2010)
Liposomes DPPC:Chol:PEG-DSPE (Zielhuis et al. 2006)
Patches Tape (Lee et al. 1997; Chung et al. 2000)
Nanofibers (Munaweera et al. 2014)
Ceramic materials Seeds (Diniz et al. 2017; Valente et al. 2011; Nogueira and Campos 2011; Nogueira and de Campos 2012; Nogueira and Campos 2016; Hosseini et al. 2013; Valente and Campos 2010; Won et al. 2005)
Membranes (Nogueira and de Campos 2012)
Generator DTPA complex (Smith et al. 1995)
Macroaggregates (Makela et al. 2003a; Park et al. 1996; McLaren et al. 1990; Sledge et al. 1977)
DTPA-Biotin (Ferro-Flores et al. 2004; Ferro-Flores et al. 2003)
EDTMP (Pedraza-Lopez et al. 2004a)
MOFDOTMP (Vosoghi et al. 2016)
Chitosan microspheres (Cho and Choi 2018)