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Table 3 Product data specification of 161TbCl3, developed in this work, compared to the commercially-available 177LuCl3

From: Production and characterization of no-carrier-added 161Tb as an alternative to the clinically-applied 177Lu for radionuclide therapy

Test

Specification of 161TbCl3

Specification of 177LuCl3 (EndolucinBeta)a

Radioactivity concentration

11–21 MBq/μL

36–44 MBq/μL

Appearance

Clear and colorless solution

Clear and colorless solution

pH

1–2

1–2

Radiolabeling yield

HPLC based on radiolabeling with161Tb of DOTANOC, molar ratio 1:4 (180 MBq/nmol)

> 99%

> 99%

Identity 161Tb (γ-ray spectrometry)

48.9 keV γ-line

74.6 keV γ-line

113 keV γ-line

208 keV γ-line

Radionuclidic purity (γ-ray spectrometry)

160Tb ≤ 0.007%

175Yb ≤ 0.01%

Radiochemical purity (radio-TLC)

> 99%

> 99%

  1. aSpecification from the EndolucinBeta certificate of analysis (ITG)