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Table 1 Quality control (QC) conditions reported in the literature and in the EP for the synthesis of [11C]MET with ultraviolet (UV) detection

From: An alternative methodology for the determination of the radiochemical purity of 11C-methionine

Author/ year

Column

Eluent

Flow (mL/min)

Run time (min)

Homocys-teine (tr in min)

Homocys-teine thiolactone (tr in min)

Methi-onine (tr in min)

EP (Council of Europe, 2014)

C18 (250 × 4.6 mm, 5 μm)

KH2PO4 1.4 g/L

1.0

10

2.1

7.0

2.6

A.Bogni et al., 2003 (Bogni et al., 2003)

YMC-Pack pro C18 (4.6 × 250 mm 5 μm)

NaH2PO4 0.05 M

1.2

nr

nr

nr

nr

Mitterhauser et al., 2005 (Mitterhauser et al., 2005)

Phenosphere 10 μm ODS(1)

KH2PO4 1.4 g/L

1–4 min:1.0; 4–15 min: 3.0

nr

4.5

nr

5.2

G. Quinoces et al., 2006 (Quincoces et al., 2006)

Supelcosil C18 (250 × 4.6 mm, 10 μm)

KH2PO4 0.01 M

1.0

nr

nr

nr

3.0

F. Lodi et al., 2007 (Lodi et al., 2007)

Nucleosil 100–3 C18 (3 × 250 mm) M-N

NaH2PO4 0.05 M:EtOH (98:2)

0.3

nr

4.5

4.3

5.5

V. Gómez et al., 2008 (Gómez et al., 2008)

Zorbax eclipse SB-Aq C18 (4.6 × 250 mm, 5 μm)

KH2PO4 1.4 g/L

1.0

13

nr

nr

4.12

F. Lodi, et al., 2008 (Lodi et al., 2008)

Nucleosil 100–3 C18 (3 × 250 mm) M-N

NaH2PO4 0.05 M:EtOH (98:2)

0.3

nr

4.5

4.3

5.5

N. Gozmina, et al., 2011 (Gomzina & Kuznetsova, 2011)

Zorbax SCX (250 × 4.6 mm)

NaH2PO4 0.01 M pH = 3

1.0

nr

4.12

20.1

5.93

C. Pascali et al., 2011 (Pascali et al., 2011)

μBondapack C18 (300 × 3.9 mm, 10 μm)

NaH2PO4 0.003 M pH = 3.1

1.0

nr

3.34

3.70

3.80

YMC-Pack Pro C18 (250 × 4.6 mm, 5 μm)

KH2PO4 0.05 M

1.0

nr

4.05

4.12

5.5

YMC-Pack Pro C18 (250 × 4.6 mm, 5 μm)

KH2PO4 0.01 M

1.0

nr

3.94

3.68

5.55

Spherisorb ODS1 (250 × 4.6 mm, 5 μm)

KH2PO4 0.01 M

1.0

nr

3.39

10.78

4.31

  1. nr not reported