EJNMMI Radiopharmacy and Chemistry

Table 3 Percentage of intact tracer in plasma and brain after 10 and 45 min (N = 2)

From: Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([¹⁸F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression

	% intact [¹⁸F]5	% intact [¹⁸F]6
10 min
Plasma	21.5 ± 0.7	14.0 ± 2.8
Brain	62.5 ± 6.4	20.5 ± 0.7
45 min
Plasma	11.5 ± 2.1	7.0 ± 0.0
Brain	68.5 ± 2.1	16.0 ± 0.7

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