Skip to main content

Advertisement

Table 3 Metabolites of (S)-[18F]9a in plasma, kidney, urine, liver, muscle and brain

From: Synthesis, radiosynthesis, in vitro and first in vivo evaluation of a new matrix metalloproteinase inhibitor based on γ-fluorinated α-sulfonylaminohydroxamic acid

30 min p.i. Organ/tissue/body fluid (% HPLC)
Plasma Kidney Urine Liver Muscle Brain
(S)-[18F]9a: tR ≈ 10.3 min 8 17 1 17 12
metabolite 1: tR ≈ 2.0 min 81 66 76 4 83 88
metabolite 2: tR ≈ 3.9 min 6 9  
metabolite 3: tR ≈ 5.5 min 2 9  
metabolite 4: tR ≈ 9.5 min 17 6 94
metabolite 5: tR ≈ 11.4 min 3 1