Table 2 MMP inhibition potencies and clogD (logD) values of lead structures and target novel hydroxamic acids

(R)-CGS 27023A

CH₃

N

20^c

8^c

1.49

(Mac Pherson et al., 1997)

(R)-CGS 25966

CH₃

CH

11^c

27^c

2.72

(Scozzafava and Supuran, 2000)

(R)-FEtO- CGS 25966

CH₂CH₂F

CH

4 ± 3

50 ± 27

2.92

2.02 ± 0.03

(Wagner et al., 2011)

(R)-2

CH₃

N

9.3 ± 2.0

8.3 ± 0.1

0.81

(Behrends et al., 2015)

(S)-2

CH₃

N

7.2 ± 0.1

4.9 ± 0.4

0.81

(Behrends et al., 2015)

(R)-9a

CH₂CH₂F

CH

10.4 ± 5.9

0.5 ± 0.3

2.23

(S)-9a

CH₂CH₂F

CH

0.3 ± 0.03

0.1 ± 0.01

2.23

1.16 ± 0.2^d