From: Synthesis, radiosynthesis, in vitro and first in vivo evaluation of a new matrix metalloproteinase inhibitor based on γ-fluorinated α-sulfonylaminohydroxamic acid
Compound
Configuration
IC50 values [nM]
MMP-2
MMP-9
CGS 27023A
R
20
8
CGS 25966
11
27
1
6.4
12.3
S
32.8
3.0
2
9.3
8.3
7.2
4.9