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Table 1 IC50 vcalues of CGS lead structures and γ-fluorinated MMP inhibitors 1 und 2 (Mac Pherson et al. 1997; Scozzafava et al. 2000; Behrends et al. 2015)

From: Synthesis, radiosynthesis, in vitro and first in vivo evaluation of a new matrix metalloproteinase inhibitor based on γ-fluorinated α-sulfonylaminohydroxamic acid

Compound

Configuration

IC50 values [nM]

MMP-2

MMP-9

CGS 27023A

R

20

8

CGS 25966

R

11

27

1

R

6.4

12.3

S

32.8

3.0

2

R

9.3

8.3

S

7.2

4.9