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Table 1 IC50 vcalues of CGS lead structures and γ-fluorinated MMP inhibitors 1 und 2 (Mac Pherson et al. 1997; Scozzafava et al. 2000; Behrends et al. 2015)

From: Synthesis, radiosynthesis, in vitro and first in vivo evaluation of a new matrix metalloproteinase inhibitor based on γ-fluorinated α-sulfonylaminohydroxamic acid

Compound Configuration IC50 values [nM]
MMP-2 MMP-9
CGS 27023A R 20 8
CGS 25966 R 11 27
1 R 6.4 12.3
S 32.8 3.0
2 R 9.3 8.3
S 7.2 4.9