Comparison of fully-automated radiosyntheses of [11C]erlotinib for preclinical and clinical use starting from in target produced [11C]CO2 or [11C]CH4

EJNMMI Radiopharmacy and Chemistry

Table 2 Comparison of synthesis procedures described in literature

Literature	[¹¹C]CH₃I Production method	Reaction time	Solvent	Temperature	Base	Molar activity	Radiochemical purity	Yield
Memon et al. 2009	not specified	5 min	DMF	120 °C	NaH	20–100 GBq/μmol	<95%	n.a.
Bahce et al. 2013	not specified	5 min	CH₃CN	80 °C	TBAH	184–587 GBq/μmol	>98%	2.18–3.48 GBq
Petrulli et al. 2013	[¹¹C]CO₂ via GE FX MeI module	5 min	DMF	120°	NaH	159 ± 48 GBq/μmol	>99%	n.a.
Slobbe et al. 2015	[¹¹C]CO₂ via LiAlH₄	5 min	DMF/CH₃CN	120 °C	TBAH	287 ± 63 GBq/μmol	>99%	13.1 ± 3.7%*