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Table 1 Ex vivo biodistribution of [68Ga]3 in mice bearing αvß3-positive U-87 MG tumors at 1 h p.i. along with blocking studies in comparison to [68Ga]Ga-NODAGA-c(RGDfK) and [68Ga]Ga-DOTA-c(RGDfK) (data taken from ref. Dumont et al. 2011). Data are expressed as %IA g− 1 and represent mean ± SD (n = 5)

From: Preparation and preclinical evaluation of a 68Ga-labelled c(RGDfK) conjugate comprising the bifunctional chelator NODIA-Me

Organ

[68Ga]3

[68Ga]Ga-NODAGA-c(RGDfK)

[68Ga]Ga-DOTA-c(RGDfK)

1 h

1 h blockade

1 h

1 h

Blood

0.54 ± 0.08

0.50 ± 0.03

0.16 ± 0.03

0.38 ± 0.07

Heart

0.31 ± 0.05

0.16 ± 0.03

0.33 ± 0.07

0.35 ± 0.08

Lung

0.62 ± 0.09

0.33 ± 0.06

0.80 ± 0.07

0.87 ± 0.12

Spleen

0.73 ± 0.05

0.34 ± 0.05

1.73 ± 0.44

1.34 ± 0.21

Liver

1.02 ± 0.13

0.37 ± 0.20

1.86 ± 0.23

1.60 ± 0.27

Pancreas

0.21 ± 0.01

0.09 ± 0.07

0.23 ± 0.08

0.29 ± 0.05

Stomach

0.54 ± 0.13

0.12 ± 0.02

1.40 ± 0.34

1.50 ± 0.36

Intestine

0.31 ± 0.01

0.13 ± 0.01

1.83 ± 0.51

1.79 ± 0.30

Kidney

1.65 ± 0.12

0.87 ± 0.16

1.98 ± 0.51

2.24 ± 0.34

Muscle

0.18 ± 0.01

0.09 ± 0.01

0.49 ± 0.29

0.29 ± 0.04

Bone

0.36 ± 0.06

0.14 ± 0.04

0.45 ± 0.21

0.35 ± 0.05

Tumor

2.10 ± 0.09

0.29 ± 0.16

5.19 ± 1.45

3.47 ± 0.78

Tumor-to-blood

3.91 ± 0.43

 

27.67 ± 7.01

9.24 ± 1.12

Tumor-to-kidney

1.27 ± 0.04

 

2.64 ± 0.31

1.57 ± 0.14

Tumor-to-liver

2.08 ± 0.18

 

2.75 ± 0.31

2.25 ± 0.37

Tumor-to-muscle

11.69 ± 0.29

 

12.80 ± 5.25

12.37 ± 1.81