Organ | [68Ga]3 | [68Ga]Ga-NODAGA-c(RGDfK) | [68Ga]Ga-DOTA-c(RGDfK) | |
---|---|---|---|---|
1 h | 1 h blockade | 1 h | 1 h | |
Blood | 0.54 ± 0.08 | 0.50 ± 0.03 | 0.16 ± 0.03 | 0.38 ± 0.07 |
Heart | 0.31 ± 0.05 | 0.16 ± 0.03 | 0.33 ± 0.07 | 0.35 ± 0.08 |
Lung | 0.62 ± 0.09 | 0.33 ± 0.06 | 0.80 ± 0.07 | 0.87 ± 0.12 |
Spleen | 0.73 ± 0.05 | 0.34 ± 0.05 | 1.73 ± 0.44 | 1.34 ± 0.21 |
Liver | 1.02 ± 0.13 | 0.37 ± 0.20 | 1.86 ± 0.23 | 1.60 ± 0.27 |
Pancreas | 0.21 ± 0.01 | 0.09 ± 0.07 | 0.23 ± 0.08 | 0.29 ± 0.05 |
Stomach | 0.54 ± 0.13 | 0.12 ± 0.02 | 1.40 ± 0.34 | 1.50 ± 0.36 |
Intestine | 0.31 ± 0.01 | 0.13 ± 0.01 | 1.83 ± 0.51 | 1.79 ± 0.30 |
Kidney | 1.65 ± 0.12 | 0.87 ± 0.16 | 1.98 ± 0.51 | 2.24 ± 0.34 |
Muscle | 0.18 ± 0.01 | 0.09 ± 0.01 | 0.49 ± 0.29 | 0.29 ± 0.04 |
Bone | 0.36 ± 0.06 | 0.14 ± 0.04 | 0.45 ± 0.21 | 0.35 ± 0.05 |
Tumor | 2.10 ± 0.09 | 0.29 ± 0.16 | 5.19 ± 1.45 | 3.47 ± 0.78 |
Tumor-to-blood | 3.91 ± 0.43 | 27.67 ± 7.01 | 9.24 ± 1.12 | |
Tumor-to-kidney | 1.27 ± 0.04 | 2.64 ± 0.31 | 1.57 ± 0.14 | |
Tumor-to-liver | 2.08 ± 0.18 | 2.75 ± 0.31 | 2.25 ± 0.37 | |
Tumor-to-muscle | 11.69 ± 0.29 | 12.80 ± 5.25 | 12.37 ± 1.81 |