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EJNMMI Radiopharmacy and Chemistry
Fig. 5 | EJNMMI Radiopharmacy and Chemistry

Fig. 5

From: Preclinical validations of [18F]FPyPEGCBT-c(RGDfK): a 18F-labelled RGD peptide prepared by ligation of 2-cyanobenzothiazole and 1,2-aminothiol to image angiogenesis

Fig. 5

MicroPET/CT images of [18F]FPyPEGCBT-c(RGDfK) in nude mice bearing subcutaneous tumours. Coronal sections of representative microPET/CT images of nude mice bearing subcutaneous U-87 MG (a, left) and SKOV-3 (a, right) tumours after an uptake time of [18F]FPyPEGCBT-c(RGDfK) of 60 ± 10 min. Tumours are outlined by dashed circles. Similar experiments were performed with injections of a blocking c(RGDfV) peptide 5 min prior to the tracer (b). c Mean SUV of [18F]FPyPEGCBT-c(RGDfK) in U-87 MG and SKOV-3 tumours at indicated times (top graph) as well as in the 60 min-blocked experiment (bottom graph). d Tumours-to-blood and Tumours-to-muscle SUV ratios were also determined for the uptake time course of [18F]FPyPEGCBT-c(RGDfK) (top graph) and the blocked experiment (bottom graph). Data are means ± SD (n ≥ 5). Statistical differences were analysed with the one-way ANOVA test followed by Dunnett’s post hoc test as compared with 0.5 h uptake time (c, d, top graphs) or with non-blocked 1 h uptake time (c, d, bottom graphs); *p < 0.05, #p < 0.001

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