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Table 1 Labeling methods and yields

From: Automation of the Radiosynthesis of Six Different 18F-labeled radiotracers on the AllinOne

Name of the radiotracer

Production runs

Average yield (d.c. %)

Specific activity mCi/μmol@EOS

Run timea (min)

Method

[18F]ISO-1

50

40 ± 5

1000–14,000

60

One vessel, one step, HPLC, SPE

[18F]FTT

40

52 ± 3

1000–35,304

55

One vessel, one step, HPLC, SPE

[18F]FTP

12

11 ± 2

2500–4680

60

One vessel, one step, HPLC, SPE

[18F]Fallypride

3

68 ± 2

2380–3200

45

One vessel, one step, HPLC, SPE

[18F]Flubatine

2

30 ± 1

3119–3220

60

One vessel, two steps, HPLC, SPE

[18F]F-Gln

25

11 ± 3

>40b

98

Two vessels, two steps, HPLC, SPE

  1. aRun time was defined from start of synthesis (radioactivity measured on QMA after radioactivity delivery) to end of synthesis (product formulated in final product vial), including drying [18F]F-, reaction, purification and formulation
  2. Starting activity ranged from 30 mCi to 1500 mCi; with 30–50 mCi for the developmental runs and 500–1500 mCi for clinical productions
  3. bBased on the limit of quantitation from UV spectra