Scheme 1From: Bone targeting compounds for radiotherapy and imaging: *Me(III)-DOTA conjugates of bisphosphonic acid, pamidronic acid and zoledronic acidSynthesis of DOTAZOL: (i) benzyl bromoacetate, DMF, Cs2CO3, 0 °C, 12 h. (ii) H2, Pd/C, MeOH, RT, 24 h. (iii) 1. PCl3 ,H3PO3, MeSO3H, 75 °C, 12 h, 2. H2O, 105 °C, 24 h. (iv) DOTA-NHS-ester, Na2CO3, 40 °C, 24 hBack to article page