Fig. 1From: Striatal phosphodiesterase 10A availability is altered secondary to chronic changes in dopamine neurotransmission[18F]JNJ42259152 BPND values after acute amphetamine treatment. Left: Transversal images of PDE10A binding in the brain at baseline conditions vs 60 min after s.c. amphetamine treatment (a) and at baseline conditions vs 5 min after i.v. amphetamine treatment (b). Images are overlaid on a VOI map and presented as averaged, parametric BPND images (Logan Reference) at baseline conditions and amphetamine treated conditions. Right: Comparison of BPND in striatum at baseline conditions and 1Â h after subcutaneous injection of amphetamine (c) and 5Â min after intravenous injection of amphetamine (d). No significant difference was foundBack to article page